- Review Article
- Cardiology
- Application of CRISPR-Cas9 gene editing for congenital heart disease
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Heeyoung Seok, Rui Deng, Douglas B. Cowan, Da-Zhi Wang
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Clin Exp Pediatr. 2021;64(6):269-279. Published online March 2, 2021
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Clustered regularly interspaced short palindromic repeats and CRISPR-associated protein 9 (CRISPR-Cas9) system has made a big step in the genome editing which still requires technical developments for the efficient applications in the many fields including congenital heart diseases (CHDs), closely related to the genomic abnormality. In this review, we tried to cover the most updated researches of CRISPR-Cas9 in the CHDs to understand the current technologies, eventually becoming therapeutic bases for the CHD patients. |
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